This is the area where Rose and I grew up as kids. It has really changed since we left home. The 4 lane road was a winding two lane road. The road went over the mountain rather than through the mountain as it does now.
The road you see here (heading away from you) is US-25E. If you keep going south on it I believe you will end up in Ashville, NC. I don't know where it goes from there.
If you look closely you can see where the road enters the mountain. The town that you see a little of is Cumberland Gap, TN.
Believe it or not there is a city under all of that fog...Middlesboro, Kentucky.